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Because these medications have a "narrow therapeutic window," meaning the dose must be very precise to be both safe and effective, anything that might interfere with their metabolism is a cause for scrutiny
RNA interference and neuromuscular diseases: a focus on hereditary transthyretin amyloidosis
Some work also suggests improved bone healing, though the soft-tissue literature is more prominent
Global protein abundance profiling by mass spectrometry Sample preparation (A) Flash frozen liver sections (~25 mg) from WT or Gclc / mice (3 biological replicates each per TMT sample) were thawed on ice and resuspended in DPBS, supplemented with protease (cOmplete, EDTA-free protease inhibitor cocktail, Roche, #11873580001) and phosphatase (PhosSTOP, Roche, #4906845001) inhibitor tablets
Sameer Naseeruddin is an MD, so for my particular medical situations, it definitely helps that he knows from a true medical standpoint what should and should not be done for me
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