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The miR-324-3p decreased the expression of GPX4 by targeting the 3'-untranslated region of GPX4 to induce ferroptosis

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Therefore the role of macrophages in immunothrombosis appears to be both in disease control as well as resolution of immunothrombosis through fibrin clot degradation

382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms