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One meta-analysis and systemic review of 26 trials published in April 2025 in JAMA Neurology suggested that they could help lower dementia risk

2 mg/week: 5 weeks per vial 4 mg/week: 2.5 weeks per vial 5 mg/week: 2 weeks per vial 8 mg/week: 1.25 weeks per vial 10 mg/week: 1 week per vial This creates a planning challenge

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Baseline renal function was normal or mildly impaired in 88% of patients and moderately impaired in 11% of patients (mean eGFR 82 mL/min/1.73 m)

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