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Hydrogels can mimic the brain's extracellular matrix, potentially supporting central nervous system delivery strategies, though blood-brain barrier penetration remains a major technical challenge

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It is not destroyed independent animal model work continues, and the HGF/c-Met mechanism has been corroborated by other labs but the specific dramatic synaptogenesis claims that made dihexa famous (the "7x BDNF" numbers) trace back to papers now under formal expressions of concern by the journals that published them

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