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The researchers showed that senescent Leydig cell accumulation is a driver of age-related testosterone decline, and that targeted elimination of these cells with FOXO4-DRI restored endocrine function

We used a modified Cochrane risk of bias tool to assess the risk of bias, used GRADE to assess the certainty of evidence, and used the Credibility of Effect Modification Analyses (ICEMAN) tool to assess the credibility of any apparent subgroup effect

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