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Not every patient needs this, but for patients with significant muscle mass concerns older adults, perimenopausal women, patients losing weight quickly at high doses it is worth considering

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The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats

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Per-protocol and as-treated analyses showed similar directions of association for anxiety and depression, although the strength of some associations varied depending on treatment persistence

This helps maximize the fat loss component of your weight change and makes inches-lost-without-weight-loss less likely because you're actively building lean mass