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They produce distinct metabolic effects that influence weight loss magnitude, body composition changes, glycemic control, and side effect patterns

There should be a low threshold for treating possible urinary tract infections

Support natural testosterone production TRT diminishes natural testosterone production but HCG reverses this effect by acting like LH and signalling the testicles (Leydig cells) to produce testosterone

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Tirzepatides SURPASS programme demonstrated superior HbA1c reductions compared to semaglutide in head-to-head type 2 diabetes trials [2]

As a result, high-risk patients may experience complementary benefits from a GLP1-RAs/SGLT2i combination [64]