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Hormone and Metabolic Research, 47 (10), 721-726

doi:10.1038/nature22378 Zhao P, Liang YL, Belousoff MJ, et al

The compound was originally developed in the 1980s at the University of Arizona

Dose reduction, medication switching to oral semaglutide ($289/month), or exploration of alternative peptides may become necessary to maintain treatment compliance and safety

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In the United States it is not FDA-approved , and as of April 23, 2026 it was removed from FDA's 503A Category 2 list of bulk substances flagged for compounding safety risks because the underlying nominations were withdrawn