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TIGAR reduces the cellular levels of fructose-2,6-bisphosphate (FRU-2,6-P2), which drives metabolism towards EMP and inhibits gluconeogenesis, thus suppressing EMP and elevating NADPH levels [65]

Low levels of B12 can contribute to irritability, depression, or mood swings

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The intracellular concentration of gamma-glutamylcysteine (GGC) is extremely low (~ 5 uM) when GS is present, thus GCL is considered the rate-limiting enzyme [6]

YC: Conceptualization, Data curation, Supervision, Validation, Writing original draft