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Nat Commun 16 , 765 (2025)

Published online 2015 Jan 22

Ghanem N, Ha AN, Fakruzzaman M, Bang JI, Lee SC, Kong IK

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(Wikipedia) In senescent cells (cells that have permanently exited the cellcycle, accumulate damage, and secrete inflammatory factors), FOXO4 expression goes up and helps bind p53 in the nucleus, preventing p53 from driving those cells into apoptosis

Researchers suggest this is due to treatment adherence, dose adjustments, and lifestyle variations, which are more difficult to control in a clinical setting