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Sin embargo, tambin es capaz de participar en la conjugacin no enzimtica de algunos productos qumicos, como en el caso de la N-acetil-p-benzoquinona imina (NAPQI), el metabolito reactivo formado por la accin del sistema citocromo P450 sobre el paracetamol (o acetaminofeno, como se conoce en los Estados Unidos)

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Designed for insertion into the rectum, it dissolves or melts within the rectal cavity to release the Glutathione for local or systemic absorption

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