How Your Genetics Relate to GLP-1 Pathways Individual variations in the GLP-1 receptor gene (GLP1R) and other peptide-pathway genes influence how effectively semaglutide works at any given dose
simulating the mean of 1000 possible sets of outcomes based on the standard errors included), changes in cost parameters, the risk equations used, time horizons, reasons for treatment intensification, and associated QoL decrements
After accounting for a wide range of potentially influential factors including patient age, sex, socioeconomic status, diabetes severity, and a history of mental ill health, use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with DPP-4 inhibitors (3.9 v 3.7 per 1000 person years, respectively) or an increased risk of suicidality compared with SGLT-2 inhibitors (4.3 v 4.6 per 1000 person years, respectively)
A., Eisenach, J
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