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Sixteen out of seventeen eligible studies were performed in adult male animals, except for one study in the anxiety model, which used adolescents [27]
Once activated, NLRP3 facilitates caspase-1 activation, which results in the conversion of pro-IL-1 and pro-IL-18 into their active forms, IL-1 and IL-18 [36]
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Extracellular matrix remodeling: GHK-Cu modulates the expression of over 4,000 genes, many of which are involved in tissue remodeling, stress response, and apoptosis