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Over-expressing anti-apoptotic Bcl2 factors has been shown to reduce HC death due to ototoxins (Cunningham et al., Purinergic Pathways Adenosine is an endogenous nucleoside present in all cells of the body that exerts its pharmacologic effects by activation of purine adenosine receptors, also present in the HCs, supporting Deiters cells and SGNs (Vlajkovic et al., 2007, 2009)
Wang C, Allegaert K, Tibboel D et al , Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults
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But you can microdose by spacing them out longer (e.g., every 10 days or two weeks)
In most cases, a missed dose can be administered within a specific time window or skipped until the next scheduled injection
