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doi: 10.1053/j.gastro.2016.10.012 137 GuntherCNeumannHNeurathMFBeckerC
GPX4, a pivotal enzyme in the antioxidant defense system, employs GSH as a reducing agent to convert peroxides peroxyl bonds into hydroxyl groups, converting peroxides into alcohols and impeding ferroptosis
Whilst extracellular A plaques, NFT, inflammation in the form or reactive astrocytes and microglia, and neuronal loss are all consistent pathological features of AD, a mechanistic link between these factors is yet to be clarified
As a result, intracellular Fe2+ accumulates, ROS levels increase, and cellular sensitivity to ferroptosis is enhanced
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