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In phase 3 adult clinical trials, most notably the SURMOUNT-1 study, tirzepatide produced significant and sustained reductions in body weight and metabolic parameters

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It stimulates certain MMPs necessary for the physiological remodeling of damaged tissue, while inhibiting the overactivation of MMPs that contributes to chronic dermal matrix degradation observed in photoaging

This connection is multifaceted: Increased Abdominal Pressure: Excess weight, particularly around the abdomen, can increase pressure on the stomach, pushing acid back into the esophagus