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Starting with a 12mg target and settling at 8mg because it provides sufficient results with better tolerability is a perfectly valid approach

Gastrointestinal adverse events - predominantly nausea, vomiting, diarrhea, and constipation - are the most common class effects, occurring in 20%-60% of patients depending on the agent and dose, and are typically of mild-to-moderate severity, dose-dependent, and most prominent during titration

This finding aligns with the notion proposed by Rose EC et al

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