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One major advantage of intramuscular injection is that its increasingly effective at raising blood levels of B12

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[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets

The published data shows meaningful but modest fat loss in clinical conditions, approximately 1 to 2 kg of additional fat loss over 12 weeks compared to placebo at 1 mg/day

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Persistent reactions warrant clinician review