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The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes (17)

Tirzepatide microdosing uses sublingual drops or gentle weekly injections at doses significantly below the standard therapeutic range

Delivery Mechanism Optimization: Future research aims to develop oral, nasal, or transdermal MOTS-c delivery systems to enhance bioavailability and long-term adherence for metabolic applications

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In a different experiment, mood conditions improved with folic acid and B12 intake

Catherwood M.A., Powell L.A., Anderson P., McMaster D, Sharpe P.C, Trimble E.R