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This is critical because droplet size determines where in the nasal cavity the drug deposits: droplets in the appropriate size range (typically 30200 m for nasal sprays) deposit in the nasal turbinates, where absorption occurs, while excessively small droplets may penetrate to the lower respiratory tract, and excessively large droplets may not clear the nasal vestibule

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Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease