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The SURMOUNT-1 trial showed 22.5% average weight loss with tirzepatide versus 14.9% with semaglutide in the STEP-1 trial

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The first bite told her something had fundamentally shifted

(PubMed) Matsuzawa Y, Kwon TG, Lennon RJ, Lerman LO, Lerman A

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The structural basis of the dominant negative phenotype of the Galphai1beta1gamma2 G203A/A326S heterotrimer