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A single injection of 42 g/kg exenatide reduced circulating levels of IFN-, TNF-, and IL-2 in mice challenged with agonistic anti-CD3 antibodies, which broadly activate T cells and provokes systemic and gut inflammation (34)

(9) Comorbidities of obesity and diabetes may also increase predisposition for falls, including peripheral neuropathy, obstructive sleep apnea, osteoarthritis, and femoral avascular necrosis

This dissociation suggests that tolerability may depend not solely on total weight loss or dose intensity, but on mechanistic distinctions between dual incretin agonism and GLP-1only therapy

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