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The estimated overdose of orally ingested iron is 300 mg/kg body weight

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DOI: Published online: August 18, 2021 1 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, MN, USA 2 Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA 3 Department of Psychiatry and Psychology, Mayo Clinic, College of Medicine, Rochester, MN, USA 4 Department of Neuroscience Program, Mayo Clinic, College of Medicine, Rochester, MN, USA Corresponding author: Doo-Sup Choi, PhD Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, 200 1st SW, MN 55905, USA / Tel: +1-507-284-5602 / Fax: +1-507-266-0824 / E-mail: [email protected] Copyright 2021 The Korean Movement Disorder Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

Absorption Following a single subcutaneous dose of 140 mg or 420 mg evolocumab administered to healthy adults, median peak serum concentrations were attained in 3 to 4 days, and estimated absolute bioavailability was 72%