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Sirtuins are a family of nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases composed of seven proteins, SIRT1-SIRT7, which are highly conserved among species

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Of the eight GPxs, GPx4 is essential for life as the mice lacking it (knock out or KO) do not survive [1, 8, 9]

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Dhupar R, Rice RD, Correa AM, Weston BR, Bhutani MS, Maru DM, Betancourt SL, Rice DC, Swisher SG , Hofstetter WL