Injuries such as sciatic nerve damage, shoulder injury related to vaccine administration (SIRVA), and localized tissue necrosis are often preventableyet they continue to occur due to poor technique, inadequate training, or improper site selection
To overcome this limitation, scientists have developed GLP-1 receptor agonists (GLP-1 RAs), such as semaglutide, tilpotide, etc., which extend the half-life to the weekly formulation level through structural modification, achieving sustained regulation
Another imminent problem is that the GLP-1RAs that are currently used in the clinical setting are biological macromolecular peptide preparations, such as exenatide and liraglutide, with high production costs that limit their clinical application (231)
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Individual response varies dramatically based on genetics, dose titration speed, and personal factors, so one patient's mild experience may differ completely from another's
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