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Early data showed a number of issues ranging from facial redness, nausea, and spontaneous erections

Assisted reproduction cohorts are intrinsically heterogeneous: cycle type, progesterone route and exposure duration, stimulation protocol, embryo ploidy/PGT status, culture media formulation, incubator conditions, and laboratory workflow can each introduce systematic variance that may be comparable to biological effects across centres and protocols, and can mask or mimic true reproductive signals [462,463,464,465]

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The patent landscape reflects intense focus on permeation enhancers, solid oral compositions, and buccal or sublingual alternatives to injection [7, 8, 9]

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