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[15] [27] In October 2025, the FDA further expanded the indication for semaglutide (as Rybelsus) to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes who are at high risk for these events

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GLP-1 receptors have been found on spinal cord microglia, which are the brain and spinal cords immune cells, and activation of those receptors appears to shift microglia from a pro-inflammatory M1 state to an anti-inflammatory M2 state [2, 16]

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Diabetes Care 30:19791987 Ahren B, Pacini G, Foley JE, Schweizer A (2005) Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year