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It's an opioid antagonist, most commonly used to treat alcohol and opioid dependence

Convenience: Semaglutide is available in a once-weekly injectable form, making it convenient for people with busy schedules

This change to the structure fixes that problem

Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Study Duration: Published weight loss trials have lasted 24-72 weeks