In the class of incretin mimetics, factors like risk of severe heart disease, heart disease history (former heart attack or stroke), A1C and weight loss needs, costs and insurance coverage, and patient preference are all important considerations when determining which drug to use
Higher doses, longer treatment, and the presence of musculoskeletal pain before treatment began were also associated with greater lean body mass decline with both drugs, the researchers found
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Long-term effects are also unknown
Scott Brunner, CEO of the Alliance for Pharmacy Compounding, a group representing pharmacies that make compounded drugs, noted in a post on LinkedIn that While adverse events do sometimes occur, as they do with FDA-approved drugs as well, legitimate compounding pharmacies operate in a compliance framework in which ensuring patient safety is both paramount and essential to the pharmacys ability to continue to serve its patients. Last month, the FDA said the shortage of tirzepatide, sold by Eli Lilly as Mounjaro for diabetes and Zepbound for obesity, had been resolved, which was expected to lead to the end of mass compounding of the medicine
Semaglutide is significantly more effective when combined with dietary changes and increased physical activity