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Cardiac muscle cells cannot synthesize L-carnitine de novo and must acquire L-carnitine exogenously via the arnitine/organic cation transporter 2 (OCTN2)

Endocrine 91 , 82 (2026)

W.ChawlaM.KimJ.HuoL.DuL.et al (2023)

In the present review, comprehensive analysis revealed a particularly intriguing phenomenon: Lactate exhibits diametrically contrasting effects on ferroptosis, promoting cell death in normal cells while conferring protection in tumor cells

By understanding the basis for missing-self recognition in these mutants, we will begin to uncover the underlying genetic basis of self tolerance and autoimmunity.