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LL-37: A host defense peptide with clinical potential

PMID: 29511665

Intranasal vitamin B12 administration is an effective and appropriate method for restoring and maintaining adequate vitamin B12 levels in elderly patients

The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research

A vitamin B12 deficiency can often lead to a feeling of extreme tiredness, lack of energy and muscle weakness alongside many other symptoms

Non-Antibiotic Periodontal Management AMPs represent a promising direction for managing periodontal disease without the collateral damage to the broader microbiome caused by systemic antibiotics