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Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity

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and thus, it could indicate that low circulating levels of IGF-1 can lead to MetS and raise the risk for CVD and T2D

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Well-designed prospective cohort studies incorporating comprehensive biomarker analyses currently represent the gold standard for assessing reproductive toxicity in human populations (81)

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