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After analyzing 31 polymorphisms in 11 genes, it has been discovered that in presence of the C allele in SLC22A4 (OCTN1 rs1050152), and the two minor alleles (G) in SLC22A5 (OCTN2 rs2631367 and rs2631372) the time to progression was significantly improved ( General Features of OCTN1 (SLC22A4) and Implications in Cancer Organic cation transporter OCTN1 is another member of the SLC22 family

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Clinical studies have shown average weight loss ranging from about 15% to over 22% of total body weight, depending on the dose and length of treatment

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