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With age, oxidative DNA damage increases, leading to excessive PARP-1 activation which depletes NAD+ reserves

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To understand how imprinting influences the immune response to repeat COVID-19 vaccination, Diamond and colleagues including first author Chieh-Yu Liang, a graduate student, studied the antibodies from mice or people who had received a sequence of COVID-19 vaccines and boosters targeting first the original and then omicron variants

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Caldeira-Brant AL, Martinelli LM, Marques MM, Reis AB, Martello R, Almeida FRCL, Chiarini-Garcia H (2020) A subpopulation of human Adark spermatogonia behaves as the reserve stem cell

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