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For many females, this age range coincides with the onset of menopause, which results in a substantial decline in levels of neuroprotective sex hormones, such as oestrogen and progesterone

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This may be in the context of sub-fertility, such as in women with polycystic ovarian syndrome or anovulation secondary to obesity, or in women who are aiming to lose weight or improve glycaemic control to improve pregnancy outcomes [20, 55]

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