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To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology

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At a dosage of 2 mg/kg given biweekly, the nanoparticle demonstrated significant monotherapy activity, reducing tumor burden to undetectable Levels after just five administrations