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On your diabetes point, the widening gap matches what I see in practice, where patients with type 2 lose less and arrive expecting the number everyone else quotes, which is a counseling problem before it is a pharmacology one

3.1 Alternative nutrient-sensing mechanisms Some nutrients stimulate intestinal hormone secretion independent of taste receptors, via pathways involving other GPCR or nutrient transporters (95, 96): Stomach: Calcium-sensing receptor (CaSR) and GPRC6A detect a broad range of amino acids and calcium, promoting gastrin and somatostatin release (89, 97)

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This creates a two-pronged stimulation, direct receptor binding plus cytokine-mediated amplification

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