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Nat Rev Clin Oncol 14, 562576 (2017)

The individual side effect rates (nausea, vomiting, diarrhea) are similar between the two compounds, but the discontinuation rate, which reflects how many people find the side effects intolerable, is significantly lower for semaglutide (5-7%) compared to retatrutide (12-18%)

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doi: 10.1126/science.150.3692.72