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A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts

For example, Bifidobacterium animalis F1-7 can upregulate acetylcarnitine levels in the gut, thereby downregulating the TLR4/NF-B pathway and reducing lipid accumulation and inflammation in foam cells, leading to a reduction in atherosclerotic plaque accumulation [129]

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This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety