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This protective mechanism is likely due to sulforaphanes ability to activate the Nrf2/ARE pathway
The most common side effects include nausea, low blood sugar, vomiting, diarrhea, feeling jittery, dizziness, headache, indigestion, constipation, and weakness
Moreover, the V717I substitution in amyloid precursor protein is a common mutation associated with familial Alzheimers disease worldwide [74,75,76]
What is the exit criterion if there is no improvement in eight weeks
While hyperkalaemia occurred more frequently with finerenone than with placebo, this was often mild or moderate and resulted in few drug discontinuations (2.3% vs 0.9%, respectively), despite study participants also being on maximum-tolerated RAS inhibitor therapy