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Comparison Summary Side-Effect Profile in Trials Reported side effects across all three compounds center on gastrointestinal events

So the upward line from semaglutide to tirzepatide to retatrutide is best read as a hypothesis strongly supported by early evidence, not as a law guaranteeing that triple agonism will end up strictly superior once the full safety and durability picture is in

For diabetic patients, this poses a substantial threat, as corticosteroids are known to induce hyperglycemia [34]

T., Raatz, S., Bomberg, E

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Appetite suppression peaks align differently with meal patterns