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The most consequential open safety question with TB-500 relates to its angiogenic mechanism: any compound that promotes new blood vessel growth carries a theoretical consideration around active or undiagnosed cancer, since tumours also depend on angiogenesis
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doi:10.3390/jcm7100304
Severely damaged red neurons, without any inflammatory reaction, were present in all animals, in more then one half of hippocampal neurons, neurons of the dentate nucleus, Purkinje cells and other cerebellar nuclei
Casey, T., Bond, J., Tighe, S., Hunter, T., Lintault, L., Patel, O., et al
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