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It represents the most abundant non-protein thiol in mammalian cells, present at millimolar concentrations (110 mM) in the cytosol 1
Glutaredoxin on the contrary, can also reduce thiols via reversible glutathionylation of the proteins ( i.e., the formation of a disulfide bond between GSH and specific cysteine residues) and can be reduced by GSH and NADPH-dependent GR [134137]
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