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Its other steps are confirming testosterone deficiency with repeat morning labs, assessing GLP-1 medical necessity, cardiovascular risk stratification, a realistic expectations discussion, and clear adverse-event reporting protocols

Melanotan II is not approved anywhere it is a research chemical with FDA warning letters and documented serious safety signals (melanoma, priapism, rhabdomyolysis, renal infarction, PRES)

The CagriSema combination is in Phase 3 trials (REDEFINE program) in the EU/USA, with approval expected 20272028

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Thais Rosa de Sousa, orcid.org/0009-0005-2858-1155 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers