Key contraindications include pregnancy and breastfeeding, with caution advised in those with thyroid disease, pancreatitis history, or severe gastrointestinal disease
and Canada and may be approved for people with obesity by the end of this year
Clinical effects of once-weekly exenatide for the treatment of type 2 diabetes mellitus
A 2024 safety review in ScienceDirect noted that tirzepatide may have slightly better GI tolerability than semaglutide, likely because of its dual mechanism ( ScienceDirect , 2024)
This article explores how GLP-1 works, how your genes influence GLP-1 levels, and how your genes interact with your response to GLP-1 RA medications for weight loss or diabetes
Rosano GMC, Tamargo J, Kjeldsen KP, Lainscak M, Agewall S, Anker SD, et al