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However, with oral supplements, it will take days to weeks to correct a deficiency

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Adaptive thermogenesis, the reduction in metabolic rate beyond what your reduced body mass predicts, further slows progress

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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly