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A cascade mechanism gets initiated leading to the downstream stimulation of chemokine and intracellular adhesion molecule (ICAM) formation following the generation of IL-l and TNF, respectively [185]

Kurbatov, Alla A

In an animal study, inhibition of the NF-B pathway led to a significant reduction in the expression of serum proinflammatory cytokines, including IL-6, IL-1 and TNF-, as well as an increase in the expression of the tight junction proteins occludin and ZO-1, thereby improving the function and structure of the intestinal mucosa

However, the effects arent permanent

(2014) showed that microglial NF-B is involved in the disease-like phenotypes progression in SOD1-G93A mice and suppression of NF-B reduces proinflammatory microglial activation (Frakes et al., 2014)