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For best results, use daily or between users

Community sources variously attribute it to dose, to the DMSO carrier in transdermal use, or to vascular effects, with no way to confirm cause in self-reports

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580,581 Clinical progression of AD is defined first by massive synapse loss and subsequently by neuronal death, which ultimately results in profound brain atrophy and is clinically manifested by severe dementia

For patients with impaired liver function or genetic variants affecting B12 metabolism, methylcobalamin may be preferable

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