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ICERs 2023 framework similarly carves out special analyses: Ultrarare diseases : For therapies affecting 20m/year in any of the first three years should trigger mandatory patient access schemes to contain costs ( [23] )

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Nevertheless, it is essential to emphasize that our study represents a preliminary snapshot based on available data and methodologies

GLP-1 therapy should not replace established antihypertensive medications and must be prescribed according to NICE guidance for licensed indications

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