10.1210/jcem.87.6.8739 103 GoldbloomD
At the in vitro level, cellular modelsincluding primary neuronal and microglial cultures, immortalized lines such as SHSY5Y (a human neuroblastoma cell line), 64 , 65 , 66 and BV2 (a murine microglial cell line), 67 and human induced pluripotent stem cell (iPSC)derived brain organoids 68 offer tractable systems for mechanistic dissection and pharmacological screening under controlled conditions
That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine
It is able to work in a similar way to our naturally occurring GLP-1 in the body and therefore has very similar effects including: Increase release of insulin when blood sugar is elevated
Beinaglutide for weight management in Chinese individuals with overweight or obesity: A phase 3 randomized controlled clinical study
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